Endocrine Abstracts

Background: Hyperprolactinemia, caused by chronic use of antipsychotics, is associated with impaired bone density and increased risk of fractures. We examined if calcium and vitamin D supplementation have influence on Prlr gene expression in the duodenum, vertebrae and kidneys in female rats with sulpiride-induced hyperprolactinemia.Methods: Wistar female rats 21 weeks old were divided into: Group S: 10 rats that were intramuscular administrated Sulpirid...

Introduction: Hyperprolactinemia (HP) is a common disorder in endocrinology. Based on the various etiology, HP could be divided into: physiological, pathological, drug-induced and idiopathic HP. Regardless of its origin, HP usually affects reproductive endocrine axis. The aim of the study was to determine differences in menstrual cycle abnormalities in patients with different causes of hyperprolactinemia.Patients and methods: The study included 81 patien...

Introduction: Physiological changes of pregnancy could be similar with classical presentation and biological confirmation of Cushing’s Syndrome (CS). To diagnose CS in pregnancy is very difficult especially in previously healthy women. Since the hypercortisolemia in the pregnancy increase maternal and foetal morbidity it is a concern for endocrinologists, gynaecologists, and paediatricians.Patient case report: Herein, we present young woman (23 year...

Introduction: Adrenal incidentalomas (AI) are tumours revealed during radiological procedures in patients without previous suspicion for adrenal disease. This study was conducted to determine the frequency of functional AI.Patients and methods: Thirty-eight patients with AI were included in the study. The following parameters were considered: patient age, gender, size and location of the tumour, and radiological characteristics of adrenal masses. In orde...

Introduction: The gut microbiota plays an important role in host metabolism, immunity, digestibility and even a behavior. Candida spec. is common resident of the gastrointestinal tract and integral part of the microbiota. Number of 101 to 103 fungal cells per g stool are considered as normal range. However, when mucosal surface is disrupted or host immunity is compromised, life-threatening invasive infection can ensue.Objec...

Introduction: The aim of this study was to assess the prevalence and predictors of prolonged QTc interval in patients with type 2 diabetes (T2D).Methods: This study included 501 consecutive T2D patients (277 males, age 60.4±8.1 years) treated in National Educational Centre for Diabetes, ‘Merkur’, Vrnjacka Banja, from September 2011 to July 2012. We analysed baseline clinical and laboratory data including: age, gender, duration of diabetes,...